Suzuki N, Fukuuchi Y, Koto A, Naganuma Y, Isozumi K, Matsuoka S, Gotoh J, Shimizu T
Department of Neurology, Keio University, Tokyo, Japan.
Neurosci Lett. 1993 Mar 5;151(1):1-3. doi: 10.1016/0304-3940(93)90030-o.
Recently, neuronal nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase has been elucidated to be the nitric oxide synthase (NOS) per se. In order to examine the existence and distribution of cerebrovascular nerve fibers containing these substances, NADPH-diaphorase histochemistry was applied to the cerebral blood vessels and the cranial ganglia known to innervate the cerebral vessels in the rat. Numerous nerve fibers with varicosities forming plexuses were observed in the circle of Willis and its branches. In addition, thick nerve bundles were seen to run along the wall of the internal ethmoidal artery. NADPH-diaphorase reaction was prominent in neurons of the sphenopalatine, otic and internal carotid ganglia. This study demonstrated, for the first time, the NADPH-diaphorase-containing nerve fibers in the cerebral vessels and ganglion cells in the parasympathetic and sensory ganglia known to innervate the cerebral vessels.
最近，已阐明神经元烟酰胺腺嘌呤二核苷酸磷酸（NADPH）-黄递酶本身就是一氧化氮合酶（NOS）。为了检测含有这些物质的脑血管神经纤维的存在和分布，将NADPH-黄递酶组织化学应用于大鼠的脑血管和已知支配脑血管的颅神经节。在Willis环及其分支中观察到许多有膨体形成丛状的神经纤维。此外，可见粗大的神经束沿筛前动脉壁走行。NADPH-黄递酶反应在蝶腭神经节、耳神经节和颈内动脉神经节的神经元中很明显。本研究首次证明了脑血管中含有NADPH-黄递酶的神经纤维以及已知支配脑血管的副交感神经节和感觉神经节中的神经节细胞。
