非同源系列抗癌药物与谷胱甘肽的结合。
Binding of non-homologous series of anticancer drugs to glutathione.
作者信息
Cserháti T
机构信息
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
出版信息
Biochem Mol Biol Int. 1994 Dec;34(6):1147-55.
The interaction of 17 anticancer drugs with reduced glutathione was studied by charge-transfer reversed-phase thin-layer chromatography and the hydrophobicity, the specific hydrophobic surface area and the relative strength of interaction was calculated. Only 7 anticancer drugs showed significant interaction with glutathione, the relative strength of interaction depended significantly neither on the hydrophobicity nor on the specific hydrophobic surface area of the drugs. As the interacting drugs are basic compounds it is reasonable to suppose that their interaction with the acidic glutathione is based on Coulombic forces. The direct binding of these drugs to glutathione makes it probable that glutathione may influence the biological activity of the bound anticancer drugs.
通过电荷转移反相薄层色谱法研究了17种抗癌药物与还原型谷胱甘肽的相互作用，并计算了疏水性、比疏水表面积和相互作用的相对强度。只有7种抗癌药物与谷胱甘肽表现出显著的相互作用，相互作用的相对强度与药物的疏水性和比疏水表面积均无显著相关性。由于相互作用的药物是碱性化合物，因此可以合理推测它们与酸性谷胱甘肽的相互作用基于库仑力。这些药物与谷胱甘肽的直接结合使得谷胱甘肽可能影响结合的抗癌药物的生物活性成为可能。
Zotero 插件