非同源系列抗癌药物与胞嘧啶的结合。

Binding of non-homologous series of anticancer drugs to cytosine.

作者信息

Cserháti T, Forgács E

机构信息

Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.

出版信息

Biochem Mol Biol Int. 1996 Oct;40(2):395-401. doi: 10.1080/15216549600201892.

DOI:10.1080/15216549600201892

PMID:8896762

Abstract

The interaction of 20 anticancer drugs with cytosine was studied by charge-transfer reversed-phase thin-layer chromatography. The hydrophobicity, the specific hydrophobic surface area and the relative strength of interaction was calculated. Significant linear correlation was found between the hydrophobicity and specific hydrophobic surface area of drugs; this means that, from the chromatographic point of view, they form a homologous series of solutes. Only eight anticancer drugs showed significant interaction with cytosine. The binding of these drugs to cytosine (and possibly to other nucleotides) might be an important interaction which plays a role in the biological activity of drugs.

摘要

通过电荷转移反相薄层色谱法研究了20种抗癌药物与胞嘧啶的相互作用。计算了药物的疏水性、比疏水表面积和相互作用的相对强度。发现药物的疏水性和比疏水表面积之间存在显著的线性相关性；这意味着，从色谱角度来看，它们形成了一系列同源溶质。只有8种抗癌药物与胞嘧啶表现出显著的相互作用。这些药物与胞嘧啶（可能还有其他核苷酸）的结合可能是一种重要的相互作用，在药物的生物活性中起作用。