用DNA探针检测沙眼衣原体和淋病奈瑟菌的比较研究（一则笔记）
A comparative study for detection of Chlamydia trachomatis and Neisseria gonorrhoeae with DNA probe (a note).
作者信息
Széll A, Tisza T, Horváth A
机构信息
Department of Dermato-Venereology, Semmelweis University School of Medicine, Budapest, Hungary.
出版信息
Acta Microbiol Immunol Hung. 1994;41(3):291-3.
A newly developed DNA probe assay (Gen-Probe Pace 2 San Diego, USA) was compared with Chlamydia trachomatis direct immunofluorescence and Neisseria gonorrhoeae culture. Detection of C. trachomatis in cervical specimens from women and urethral specimens from men showed 23% positivity out of 313 cases. Out of the 69 positive cases 40 were positive with both examinations, in 29 cases only with DNA probe. Examinations of N. gonorrhoeae in 254 patients gave 98% positivity. Sensitivity of DNA probe assay was 100%, specificity was 97.8%. On the basis of preliminary data Gen-Probe is suitable for the detection of both causative agents.
一种新开发的DNA探针检测法（美国圣地亚哥Gen-Probe Pace 2）与沙眼衣原体直接免疫荧光法及淋病奈瑟菌培养法进行了比较。对女性宫颈标本和男性尿道标本进行沙眼衣原体检测，在313例病例中阳性率为23%。在69例阳性病例中，40例两种检测方法均为阳性，29例仅DNA探针检测为阳性。对254例患者进行淋病奈瑟菌检测，阳性率为98%。DNA探针检测法的灵敏度为100%，特异性为97.8%。基于初步数据，Gen-Probe适用于两种病原体的检测。
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