Pituch-Noworolska A, Miezyński W
Department of Clinical Immunology and Microbiology, Polish-American Childrens Hospital, Kraków.
Pol J Pathol. 1994;45(4):257-61.
The immunological classification of 28 high grade non-Hodgkin's lymphomas (NHL) in children was shown. The morphological classification was based on Working Formulation, the immunological classification--on acute lymphoblastic leukemia subtypes. The phenotypes were assayed cytofluorometrically with monoclonal antibodies and compared to ontogenic stages in B and T cell development. Small non-cleaved cell lymphoma (Burkitt's type) was seen in 13 patients, lymphoblastic lymphoma in 12 patients, low differentiated in 3 patients. Immunological classification showed B-lymphocyte origin of blast cells in 15 patients including 11 small non-cleaved Burkitt's lymphoma (mature B and cALL phenotype), 3 undifferentiated cases (pro-B and mature B cell) and 1 case of lymphoblastic lymphoma (cALL type). T-cell origin of blast cells was demonstrated in 13 patients. The immunological classification used routinely was helpful in selection of patients with unfavourable prognosis. The more precise description of blast cells was valuable for better adjustment of therapy and better prognosis.
展示了28例儿童高级别非霍奇金淋巴瘤（NHL）的免疫分类。形态学分类基于工作分类法，免疫分类基于急性淋巴细胞白血病亚型。用单克隆抗体通过细胞荧光法检测表型，并与B细胞和T细胞发育的个体发生阶段进行比较。13例患者为小无裂细胞淋巴瘤（伯基特型），12例为淋巴母细胞淋巴瘤，3例为低分化型。免疫分类显示15例患者的原始细胞起源于B淋巴细胞，包括11例小无裂伯基特淋巴瘤（成熟B和普通型急性淋巴细胞白血病表型）、3例未分化病例（前B和成熟B细胞）和1例淋巴母细胞淋巴瘤（普通型急性淋巴细胞白血病类型）。13例患者的原始细胞起源于T细胞。常规使用的免疫分类有助于选择预后不良的患者。对原始细胞更精确的描述对于更好地调整治疗和改善预后很有价值。
