Iezzoni J C, Fechner R E
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, USA.
Surg Oncol Clin N Am. 1995 Jan;4(1):1-14.
The science of medicine is constantly evolving. Surgical pathology must respond to these changes. For example, incisional biopsies once taken during an open surgical procedure are now being replaced by FNA biopsies performed on the outpatient. Pathologists are being asked to diagnose lesions on smaller pieces of tissue and fewer cells. Advances in molecular biology are allowing diseases to be examined at the molecular level. The pathologist is now asked to integrate this molecular data into his or her diagnostic process (e.g., lymphomas). The impact on the pathologist of the increased complexity imposed on examination of tissues cannot be overstated. Despite these difficulties, diagnosis always comes down to the integration of the morphologic features with the clinical findings. As such, the diagnosis will always depend on close teamwork between the surgeon and the pathologist.
医学科学在不断发展。外科病理学必须顺应这些变化。例如，曾经在开放手术过程中进行的切开活检，如今正被门诊进行的细针穿刺活检（FNA）所取代。病理学家需要在更小的组织块和更少的细胞上诊断病变。分子生物学的进展使得能够在分子水平上检查疾病。现在要求病理学家将这些分子数据整合到其诊断过程中（例如淋巴瘤）。组织检查复杂性增加对病理学家的影响再怎么强调也不为过。尽管存在这些困难，但诊断归根结底还是形态学特征与临床发现的整合。因此，诊断始终依赖于外科医生和病理学家之间的密切团队合作。
