Perl Daniel P
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Mt Sinai J Med. 2007 Apr;74(1):22-6. doi: 10.1002/msj.20007.
Over the years, pathologists have served to make morphologic diagnoses for clinicians when provided with a biopsy or surgically resected tissue specimen. Traditionally, pathologists have used a series of morphologic techniques and relied on the microscopic appearance of resected tissues to determine a pathologic diagnosis and, with respect to neoplastic lesions, provide predictions of the potential growth pattern that might be anticipated. With the introduction of the techniques of molecular biology in medicine, the role of the pathologist has changed as have the tools available for characterizing pathologic specimens. With the pathologist's unique perspective on disease processes and access to tissue specimens from the operating room, he has become a key player in the area of translational and personalized medicine and the development of new approaches to diagnosis and translational research.
多年来，病理学家在获得活检或手术切除的组织标本后，一直为临床医生进行形态学诊断。传统上，病理学家使用一系列形态学技术，并依靠切除组织的显微镜外观来确定病理诊断，对于肿瘤性病变，还要预测可能预期的潜在生长模式。随着分子生物学技术在医学中的引入，病理学家的角色发生了变化，用于表征病理标本的工具也发生了变化。凭借病理学家对疾病过程的独特视角以及从手术室获取组织标本的途径，他已成为转化医学和个性化医学领域以及新诊断方法和转化研究发展的关键参与者。
