Yoshida A, Morozumi K, Takeda A, Koyama K, Oikawa T
Division of Nephrology, Nagoya Daini Red Cross Hospital, Japan.
Clin Ther. 1994 Nov-Dec;16(6):1000-6.
We investigated the cause of membranous glomerulonephritis (MGN) in 24 patients with rheumatoid arthritis (RA). The class or stage of RA was diagnosed using the criteria of the American Rheumatism Association, and MGN was diagnosed using renal biopsy. Renal biopsy and laboratory findings, including serologic analysis, were evaluated. Eighteen patients had previously received one of the following antirheumatic agents: bucillamine (n = 13), D-penicillamine (n = 3), or gold (n = 2). The renal lesions of all 24 patients resembled lesions seen with idiopathic MGN on examination by light microscopy, electron microscopy, and immunofluorescence. We concluded that patients with RA are predisposed to develop MGN, whether or not they receive antirheumatic agents.
我们调查了24例类风湿关节炎（RA）患者发生膜性肾小球肾炎（MGN）的原因。采用美国风湿病协会的标准诊断RA的类别或阶段，通过肾活检诊断MGN。评估了肾活检及包括血清学分析在内的实验室检查结果。18例患者此前曾使用过以下抗风湿药物之一：青霉胺（n = 13）、D-青霉胺（n = 3）或金制剂（n = 2）。在光镜、电镜和免疫荧光检查中，所有24例患者的肾脏病变均类似于特发性MGN所见的病变。我们得出结论，无论是否接受抗风湿药物治疗，RA患者均易发生MGN。
