Lambert G A, Michalicek J
Institute of Neurological Sciences, Prince Henry Hospital, Australia.
Cephalalgia. 1994 Dec;14(6):430-6; discussion 393-4. doi: 10.1046/j.1468-2982.1994.1406430.x.
These experiments were designed to investigate a possible mechanism linking the phenomenon of cortical spreading depression with activation of the trigeminal sensory system in migraine. Blood flow in the cortex and middle meningeal artery was measured in cats before and during propagation of a wave of cortical spreading depression, initiated by cortical pin-prick. This caused a transient propagated increase in cortical blood flow. Cortical spreading depression was accompanied by a decrease in blood flow in the middle meningeal artery, sometimes to very low levels. The results suggest that the pain of migraine could arise from dural ischemia induced by cortical spreading depression.
这些实验旨在研究一种可能的机制，该机制将皮质扩散性抑制现象与偏头痛中三叉神经感觉系统的激活联系起来。在猫身上，通过皮层针刺引发皮质扩散性抑制波之前和期间，测量皮层和脑膜中动脉的血流。这导致皮层血流出现短暂的扩散性增加。皮质扩散性抑制伴随着脑膜中动脉血流减少，有时会降至非常低的水平。结果表明，偏头痛的疼痛可能源于皮质扩散性抑制引起的硬脑膜缺血。
