离子通道与偏头痛
Ion channels and migraine.
作者信息
Yan Jin, Dussor Gregory
机构信息
Department of Pharmacology, University of Washington, Seattle, WA, USA.
出版信息
Headache. 2014 Apr;54(4):619-39. doi: 10.1111/head.12323.
Abstract
Migraine is one of the most common neurological disorders. Despite its prevalence, the basic physiology of the molecules and mechanisms that contribute to migraine headache is still poorly understood, making the discovery of more effective treatments extremely difficult. The consistent presence of head-specific pain during migraine suggests an important role for activation of the peripheral nociceptors localized to the head. Accordingly, this review will cover the current understanding of the biological mechanisms leading to episodic activation and sensitization of the trigeminovascular pain pathway, focusing on recent advances regarding activation and modulation of ion channels.
摘要
偏头痛是最常见的神经系统疾病之一。尽管其发病率很高，但导致偏头痛头痛的分子和机制的基本生理学仍知之甚少，这使得发现更有效的治疗方法极其困难。偏头痛期间头部特定疼痛的持续存在表明，位于头部的外周伤害感受器的激活起着重要作用。因此，本综述将涵盖目前对导致三叉神经血管疼痛通路发作性激活和敏化的生物学机制的理解，重点关注离子通道激活和调节方面的最新进展。
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