左旋多巴治疗慢性精神分裂症的双盲试验。
Double blind trial of L-dopa in chronic schizophrenia.
作者信息
Buchanan F H, Parton R V, Warren J W, Baker E P
出版信息
Aust N Z J Psychiatry. 1975 Dec;9(4):269-71. doi: 10.3109/00048677509159861.
PMID:769772
Abstract
A double blind study in 28 patients with chronic schizophrenia was carried out comparing L-dopa (up to 1250 mgm daily) with placebo (both groups continuing to receive regular neuroleptic medication) over a six week period. Assessments by the psychiatrists and psychologist using Rockland and Pollin Rating Scale showed differential improvement of insignificant proportions but the nurse's ratings showed clearly significant improvement in the subject group.
摘要
对28名慢性精神分裂症患者进行了一项双盲研究，在六周时间内将左旋多巴（每日剂量高达1250毫克）与安慰剂进行比较（两组均继续接受常规抗精神病药物治疗）。精神科医生和心理学家使用罗克兰和波林评定量表进行的评估显示，改善程度存在差异，但比例不显著，而护士的评定显示，受试组有明显显著的改善。
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