Makino M, Ohta S, Zenda H
Department of Research and Development, Nicca Chemical Co., Ltd., Bunkyo, Fukui, Japan.
Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2472-4. doi: 10.1248/cpb.42.2472.
In the previous paper, we described the synthesis of new quaternary ammonium slats with antimicrobial activity: N-alkyl-N-2-hydroxyethyl-N,N-dimethylammonium butyl phosphate (4) and N-alkyl-N-(2-hydroxy-3-phenoxy)-propyl-N,N-dimethylammonium butyl phosphate (5). In this study, we examined the relationship between the MIC (minimum inhibitory concentration) of these new cationic disinfectants, 4 (six compounds) and 5 (three compounds), and the xi-potential against Escherichia coli in solutions of these compounds. The MIC values of these disinfectants against E. coli were highly correlated with the concentration that induced electric charge inversion (xi-potential=0) of E. coli from negative to positive.
在之前的论文中，我们描述了具有抗菌活性的新型季铵盐的合成：N-烷基-N-2-羟乙基-N,N-二甲基铵磷酸丁酯（4）和N-烷基-N-(2-羟基-3-苯氧基)丙基-N,N-二甲基铵磷酸丁酯（5）。在本研究中，我们考察了这些新型阳离子消毒剂4（六种化合物）和5（三种化合物）的最低抑菌浓度（MIC）与这些化合物溶液中大肠杆菌的ξ-电位之间的关系。这些消毒剂对大肠杆菌的MIC值与使大肠杆菌电荷从负向正反转（ξ-电位 = 0）的浓度高度相关。
