对乙酰氨基酚对大鼠睾丸和肺中谷胱甘肽水平的影响。
Effect of acetaminophen on glutathione levels in rat testis and lung.
作者信息
Micheli L, Cerretani D, Fiaschi A I, Giorgi G, Romeo M R, Runci F M
机构信息
Institute of Pharmacology, University of Siena, Italy.
出版信息
Environ Health Perspect. 1994 Nov;102 Suppl 9(Suppl 9):63-4. doi: 10.1289/ehp.94102s963.
Abstract
Glutathione (GSH) levels in rat testis and lung after oral administration (3 g/kg) of acetaminophen (APAP) were studied. At the administered dose APAP is present in each organ and influences the GSH levels. APAP value of 114 micrograms/g was obtained in testis at 6 hr (peak time); in the lung the Cmax was 92 mu/g at 8 hr and this value lasted several hours longer than that in testis. GSH levels are also affected differently in the organs studied after APAP administration; the lungs seem to be the primary organ undergoing the depleting action of APAP. This process could not only cause toxicity, but also predispose those organs to the action of toxic compounds responsible for specific pathologies.
摘要
研究了大鼠口服对乙酰氨基酚（APAP，3 g/kg）后睾丸和肺中谷胱甘肽（GSH）的水平。在给药剂量下，APAP存在于每个器官中并影响GSH水平。在6小时（峰值时间）时，睾丸中的APAP值为114微克/克；在肺中，8小时时的Cmax为92微克/克，且该值持续的时间比睾丸中的长几个小时。APAP给药后，所研究器官中的GSH水平也受到不同影响；肺似乎是经历APAP消耗作用的主要器官。这个过程不仅会导致毒性，还会使这些器官更容易受到导致特定病理的有毒化合物的作用。
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