Richter W S, Cordes M, Calder D, Eichstaedt H, Felix R
Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Germany.
Eur J Nucl Med. 1995 Jan;22(1):49-55. doi: 10.1007/BF00997247.
The aim of this study was to assess whether a clinically relevant change in myocardial sestamibi activity could be documented within the first 120 min following injection (p.i.). In 17 patients planar anterior imaging of the heart was performed 5 min and 120 min p.i. During this time interval, mean decay-corrected myocardial activity declined to 77.9% +/- 9.7% after stress and to 85.7% +/- 7.9% after injection at rest (P < 0.05). In 19 patients with angiographically documented coronary artery disease, single-photon emission tomography was performed 5 min and 120 min after injection at maximum stress. For analysis, sestamibi activity was scored semiquantitatively in six left ventricular segments. Furthermore, sestamibi uptake was assessed quantitatively using a circumferential profile method. In 35 of 114 segments the score improved within 120 min p.i. (early fill-in); in these segments relative sestamibi activity rose from 69.9% +/- 22.5% to 74.5% +/- 20.8% (P < 0.01). In five patients this early fill-in was the only sign of exercise-induced hypoperfusion. In 7 of 114 segments the score deteriorated 120 min p.i. (early tracer washout); in these segments relative sestamibi activity declined from 85.6% +/- 9.9% to 80.1% +/- 10.7% (P < 0.02). In three of four patients with early tracer washout the corresponding coronary artery was significantly narrowed. In conclusion, a global myocardial sestamibi washout was registered within the first 120 min after injection. A fill-in of initial defects as well as an early tracer loss could be detected in a relevant number of patients with chronic coronary artery disease during the first 2 h p.i.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是评估在注射后最初120分钟内是否能记录到心肌 sestamibi 活性的临床相关变化。对17例患者在注射后5分钟和120分钟进行心脏平面前位成像。在此时间间隔内，应激后经衰减校正的平均心肌活性降至77.9%±9.7%，静息注射后降至85.7%±7.9%（P<0.05）。对19例经血管造影证实患有冠状动脉疾病的患者，在最大应激注射后5分钟和120分钟进行单光子发射断层扫描。为进行分析，在六个左心室节段对 sestamibi 活性进行半定量评分。此外，使用圆周轮廓法对 sestamibi 摄取进行定量评估。在114个节段中的35个节段，评分在注射后120分钟内改善（早期填充）；在这些节段中，相对 sestamibi 活性从69.9%±22.5%升至74.5%±20.8%（P<0.01）。在5例患者中，这种早期填充是运动诱发灌注不足的唯一迹象。在114个节段中的7个节段，评分在注射后120分钟恶化（早期示踪剂洗脱）；在这些节段中，相对 sestamibi 活性从85.6%±9.9%降至80.1%±10.7%（P<0.02）。在4例早期示踪剂洗脱患者中的3例，相应冠状动脉明显狭窄。总之，在注射后最初120分钟内记录到整体心肌 sestamibi 洗脱。在注射后最初2小时内，在相当数量的慢性冠状动脉疾病患者中可检测到初始缺损的填充以及早期示踪剂丢失。（摘要截断于250字）
