Sanglier M, Nicolis G
Biophys Chem. 1976 Mar;4(2):113-21. doi: 10.1016/0301-4622(76)85001-6.
A genetic regulatory model involving a positive feedback (via induction) and a negative feedback (via catabolite repression) is analyzed and applied to the problem of the lac operon regulation in E. coli. Damped and sustained oscillations of the limit cycle type are found along with threshold phenomena corresponding to multiple limit cycles or to multiple steady states, for values of the parameters compatible with experimental data. A comparison with the observations of Knorre and Goodwin is outlined.
分析了一个涉及正反馈（通过诱导）和负反馈（通过分解代谢物阻遏）的基因调控模型，并将其应用于大肠杆菌中乳糖操纵子调控的问题。对于与实验数据相符的参数值，发现了极限环类型的阻尼振荡和持续振荡，以及对应于多个极限环或多个稳态的阈值现象。概述了与Knorre和Goodwin的观察结果的比较。
