两个小鼠同源框基因Tlx-1和Tlx-2在小鼠19号和6号染色体上的遗传定位。

Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6.

作者信息

Wen X Y, Tang S, Breitman M L

机构信息

Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

出版信息

Genomics. 1994 Nov 15;24(2):388-90. doi: 10.1006/geno.1994.1634.

DOI:10.1006/geno.1994.1634

PMID:7698766

Abstract

We have previously cloned two mouse homeobox genes Tlx-1 (T-cell leukemia homeobox gene-1) and a related gene Tlx-2 based on their homology to human HOX11, a putative proto-oncogene involved in human T-cell leukemia. We have mapped Tlx-1 to mouse chromosome 19 and Tlx-2 to chromosome 6 by linkage analysis using an interspecific backcross (C57BL/6J x Mus spretus) F1 x M. spretus. The proposed gene orders and genetic distances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4-(5.32 cM)-Tlx-1- (3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tcrb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6.

摘要

我们之前基于与人类HOX11（一种参与人类T细胞白血病的假定原癌基因）的同源性，克隆了两个小鼠同源异型盒基因Tlx-1（T细胞白血病同源异型盒基因-1）和一个相关基因Tlx-2。我们通过种间回交（C57BL/6J×小家鼠）F1×小家鼠的连锁分析，将Tlx-1定位到小鼠19号染色体，将Tlx-2定位到6号染色体。Tlx-1和Tlx-2的拟基因顺序和遗传距离分别为：着丝粒19-Lpc-1-（25.53厘摩）-Pltr-4-（5.32厘摩）-Tlx-1-（3.19厘摩）-Ins-1-（7.45厘摩）-Xmv-18，以及着丝粒6-Tcrb-（12.90厘摩）-Mltr-3-（10.75厘摩）-Tlx-2-（18.42厘摩）-Xmv-6。