Hashikawa K, Matsumoto M, Moriwaki H, Oku N, Okazaki Y, Seike Y, Uehara T, Tanabe H, Ohie Y, Kamada T
Department of Nuclear Medicine, Osaka University Medical School, Suita, Japan.
J Nucl Med. 1995 Apr;36(4):690-6.
To better understand cortical perfusion, we developed a method for a three-dimensional display technique with 99mTc-hexamethylpropyleneamine oxime (HMPAO) SPECT.
Twelve patients with higher cortical dysfunction due to Alzheimer's disease and 18 age-matched controls were examined. Data acquisition was performed after intravenous injection of 740 MBq of 99mTc-HMPAO. After reconstructing the transaxial images, the three-dimensional images were obtained by modified volume rendering, where the surfaces were displayed in the corresponding colors as the maximum cortical value within a depth of 2 cm.
In the control studies, almost all surface cortices were over 60% of the maximum cerebellar value. In Alzheimer's disease patients, areas of perfusion below 60% were detected in the temporo-parietal lesions and frontal lobe lesions in 6 of 12. These findings correlated with the neurological dysfunction.
This method provides realistic three-dimensional information about surface cortical perfusion, which was found to be useful in clinical investigations of higher cortical dysfunction due to degenerative or cerebrovascular diseases.
为了更好地理解皮质灌注，我们开发了一种利用99mTc-六甲基丙烯胺肟（HMPAO）单光子发射计算机断层扫描（SPECT）的三维显示技术方法。
对12例因阿尔茨海默病导致高级皮质功能障碍的患者和18例年龄匹配的对照者进行检查。静脉注射740MBq的99mTc-HMPAO后进行数据采集。重建横断面图像后，通过改良容积再现获得三维图像，其中表面以相应颜色显示为2cm深度内的最大皮质值。
在对照研究中，几乎所有表面皮质均超过小脑最大皮质值的60%。在阿尔茨海默病患者中，12例中有6例在颞顶叶病变和额叶病变中检测到灌注低于60%的区域。这些发现与神经功能障碍相关。
该方法提供了有关表面皮质灌注的逼真三维信息，发现其在因退行性或脑血管疾病导致的高级皮质功能障碍的临床研究中有用。
