在类风湿性滑膜细胞和组织中未发现腺病毒六邻体区域的证据。
No evidence of adenoviral hexon regions in rheumatoid synovial cells and tissue.
作者信息
Nikkari S, Luukkainen R, Nikkari L, Skurnik M, Toivanen P
机构信息
Department of Medical Microbiology, Turku University, Turku and Satalinna Hospital, Harjavalta, Finland.
出版信息
J Rheumatol. 1994 Dec;21(12):2179-83.
OBJECTIVE
To investigate whether adenoviral DNA is present in synovial specimens from patients with rheumatoid arthritis (RA).
METHODS
Synovial fluid (SF) cells from 53 patients with early RA (duration less than 1 year) and synovial tissue samples of 20 patients with advanced RA were studied by using polymerase chain reaction for the presence of adenoviral DNA. The controls were 21 patients with other arthropathies.
RESULTS
No adenoviral DNA was found in the SF leukocytes or synovial tissue of any of the patients with arthritis.
CONCLUSION
These findings do not indicate that adenoviruses play a role in the etiology of RA. However, they do not exclude adenoviruses as an occasional cause of persistent or recurrent inflammatory arthritis.
目的
研究类风湿关节炎（RA）患者滑膜标本中是否存在腺病毒DNA。
方法
采用聚合酶链反应检测53例早期RA（病程小于1年）患者的滑液（SF）细胞以及20例晚期RA患者的滑膜组织样本中腺病毒DNA的存在情况。对照组为21例患有其他关节病的患者。
结果
所有关节炎患者的SF白细胞或滑膜组织中均未发现腺病毒DNA。
结论
这些发现并不表明腺病毒在RA的病因中起作用。然而，它们并不排除腺病毒作为持续性或复发性炎症性关节炎的偶尔病因。
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