原发性抗磷脂综合征中的T淋巴细胞亚群

T lymphocyte subsets in primary antiphospholipid syndrome.

作者信息

Papo T, Piette J C, Legac E, Frances C, Grenot P, Debre P, Godeau P, Autran B

机构信息

Department of Internal Medicine, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

出版信息

J Rheumatol. 1994 Dec;21(12):2242-5.

PMID:7699624

Abstract

OBJECTIVE

To study T, natural killer (NK) and B blood cell subsets in primary antiphospholipid syndrome (APS).

METHODS

We studied 10 patients with primary APS and 12 healthy subjects. Blood lymphocytes counts, proportions of B cells (CD19+), total CD5 and CD5 B cells, NK cells (CD16+CD56+), T cells (CD3+), CD4+ helper (naive CD4+CD45RA+, memory CD4+CD45RO+ and CD4+CD29+, activated CD4+CD25+), CD8 (immunoregulatory CD8+CD57+, activated CD8+HLA-DR+) T cell subsets were measured by flow cytometry analysis.

RESULTS

In the primary APS group, we observed a lower total lymphocyte count (p = 0.009), an expansion of naive CD4 cells (p = 0.025), a lower proportion of memory CD4 cells (p = 0.04) and an increased ratio of naive/memory CD4 cells (p = 0.015).

CONCLUSION

Blood T cells phenotypes in primary APS differ markedly from healthy controls, indicating that immunologic abnormalities in primary APS might extend beyond autoantibody production.

摘要

目的

研究原发性抗磷脂综合征（APS）中的T细胞、自然杀伤（NK）细胞和B淋巴细胞亚群。

方法

我们研究了10例原发性APS患者和12名健康受试者。通过流式细胞术分析测定血液淋巴细胞计数、B细胞（CD19+）比例、总CD5和CD5+B细胞、NK细胞（CD16+CD56+）、T细胞（CD3+）、CD4+辅助性T细胞（初始CD4+CD45RA+、记忆性CD4+CD45RO+和CD4+CD29+、活化CD4+CD25+）、CD8（免疫调节性CD8+CD57+、活化CD8+HLA-DR+）T细胞亚群。