Boyer G S, Templin D W, Cornoni-Huntley J C, Everett D F, Lawrence R C, Heyse S F, Miller M M, Goring W P
Alaska Area Native Health Service, Anchorage.
J Rheumatol. 1994 Dec;21(12):2292-7.
To estimate the prevalence of spondyloarthropathies (SpA) in 2 Alaskan Eskimo populations, using improved methodology for case ascertainment and new, more inclusive classification criteria.
Through existing rheumatic disease registries, health care providers and the Alaska Area Native Health Service (AANHS) computerized patient information system, we identified all native residents of the 2 study regions with a diagnosis of any inflammatory arthritis or problems characteristic of SpA, such as iritis or persistent back pain. Individuals with such diagnoses or problems were evaluated in clinic, according to a standardized protocol (interview, examination), and by medical record review, pelvic radiography and laboratory tests. Each case was evaluated according to standard diagnostic criteria for the individual disease entities and by the Amor and European Spondylarthropathy Study Group (ESSG) preliminary classification criteria for SpA.
We identified 104 cases of SpA in the combined Eskimo populations, an overall prevalence of 2.5% in adults aged 20 and over. Both undifferentiated (USpA) and reactive SpA were more common than ankylosing spondylitis (AS).
Using the new criteria and a more effective approach to case ascertainment we found the prevalence of SpA to be about twice that found in our earlier studies of adult Eskimo populations. The prevalence of SpA was very similar in men and women. Despite the known high prevalence (25-40%) of HLA-B27 in the study populations we did not find the prevalence of any form of SpA to be as strikingly high as that of AS (6-10%) for the Canadian Haida.
采用改进的病例确诊方法和更新的、涵盖范围更广的分类标准，估算阿拉斯加两个爱斯基摩人群中脊柱关节病（SpA）的患病率。
通过现有的风湿病登记系统、医疗服务提供者以及阿拉斯加地区原住民健康服务中心（AANHS）的计算机化患者信息系统，我们识别出两个研究区域内所有被诊断患有任何炎性关节炎或具有SpA特征性问题（如虹膜炎或持续性背痛）的原住民居民。对有此类诊断或问题的个体，按照标准化方案（访谈、检查）进行临床评估，并通过病历审查、骨盆X光摄影和实验室检查进行评估。每个病例均根据各疾病实体的标准诊断标准以及SpA的阿穆尔（Amor）和欧洲脊柱关节病研究组（ESSG）初步分类标准进行评估。
在合并的爱斯基摩人群中，我们识别出104例SpA病例，20岁及以上成年人的总体患病率为2.5%。未分化脊柱关节病（USpA）和反应性SpA均比强直性脊柱炎（AS）更为常见。
使用新的标准和更有效的病例确诊方法，我们发现SpA的患病率约为我们早期对成年爱斯基摩人群研究中所发现患病率的两倍。SpA在男性和女性中的患病率非常相似。尽管已知研究人群中HLA - B2７的患病率很高（25 - 40%），但我们并未发现任何形式的SpA患病率像加拿大海达族的AS患病率（6 - 10%）那样显著高。
