俄罗斯楚科奇原住民中脊柱关节病和HLA - B27的患病率
Prevalence of spondyloarthropathies and HLA-B27 in the native population of Chukotka, Russia.
作者信息
Alexeeva L, Krylov M, Vturin V, Mylov N, Erdesz S, Benevolenskaya L
机构信息
Department of Epidemiology and Genetics Rheumatic Diseases, Institute of Rheumatology RAMS, Moscow, Russia.
出版信息
J Rheumatol. 1994 Dec;21(12):2298-300.
OBJECTIVE
We sought to determine the prevalence and nature of spondyloarthropathies (SPA) and the prevalence of HLA-B27 in the native selected circumpolar population of Chukotka, Russia.
METHODS
We conducted a cross sectional study that included medical examinations and interviews of 355 of 498 (71.3%) native residents of 2 Eastern Chukotka settlements, Enmelen and Nunligran.
RESULTS
Among them were 268 Chukchas, 7 Eskimos, and 80 subjects of mixed race. There were 9 subjects (2.5%) with SPA, 3 of 7 Chukchas had ankylosing spondylitis (AS) (1.1%), 2 reactive arthritis (ReA), 2 with undifferentiated SPA. Among the mixed race persons one Chukcha-Eskimo had AS, one Eskimo-Russian had psoriatic arthritis (PsA). We found a high percentage of HLA-B27 antigen in the population, 34% in Chukcha natives and 25% in mixed race.
CONCLUSION
Our data complement other studies of circumpolar populations and reinforce the reported high prevalences of SPA and HLA-B27 among those populations.
目的
我们试图确定俄罗斯楚科奇地区本土极地人群中脊柱关节病（SPA）的患病率和性质，以及HLA - B27的患病率。
方法
我们进行了一项横断面研究，对楚科奇东部两个定居点恩梅伦和努利格兰的498名本土居民中的355人（71.3%）进行了医学检查和访谈。
结果
其中有268名楚科奇人、7名爱斯基摩人以及80名混血儿。有9名受试者（2.5%）患有SPA，7名楚科奇人中有3人患有强直性脊柱炎（AS）（1.1%），2人患有反应性关节炎（ReA），2人患有未分化型SPA。在混血儿中，一名楚科奇 - 爱斯基摩人患有AS，一名爱斯基摩 - 俄罗斯人患有银屑病关节炎（PsA）。我们发现该人群中HLA - B27抗原的比例较高，楚科奇本地人中为34%，混血儿中为25%。
结论
我们的数据补充了其他关于极地人群的研究，并强化了报道中这些人群中SPA和HLA - B27的高患病率。
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