Wolfe F, Russell I J, Vipraio G, Ross K, Anderson J
University of Kansas School of Medicine, Wichita Arthritis Research and Clinical Centers, USA.
J Rheumatol. 1997 Mar;24(3):555-9.
To investigate the association of serum serotonin with fibromyalgia (FM), and to study the relationship of serotonin to clinical variables associated with FM.
Serum samples (n = 292) were obtained on subjects without pain, with regional pain, and with widespread pain during a population survey. The tender point examination was made according to American College of Rheumatology examination criteria by an examiner blind to the subjects' complaints. Serotonin was determined by high performance liquid chromatography coupled to an electrochemical detector.
No associations between clinical variables and serotonin levels were found in the group as a whole. Subjects with FM had lower serotonin levels unadjusted (p = 0.019) and adjusted for age and sex (p = 0.059) than those without FM. Within the FM group, associations between serotonin and tender point count (r = 0.563) and depression (r = 0.549) were noted, but the direction of association was opposite to previous reports and expectations.
Serum serotonin levels are significantly lower in persons with FM compared to those without FM, but the range of values is wide. Difficult to explain correlations with reversed directions are noted for tender point count, dolorimetry, depression, and anxiety among those with FM. Serotonin is not correlated with any clinical variables in the general population, and separate pain groups cannot be distinguished.
探讨血清5-羟色胺与纤维肌痛（FM）的关联，并研究5-羟色胺与FM相关临床变量之间的关系。
在一项人群调查中，采集了无疼痛、有局部疼痛和有广泛疼痛的受试者的血清样本（n = 292）。由对受试者主诉不知情的检查者根据美国风湿病学会检查标准进行压痛点检查。采用高效液相色谱-电化学检测法测定5-羟色胺。
在整个研究组中，未发现临床变量与5-羟色胺水平之间存在关联。未经调整（p = 0.019）以及经年龄和性别调整后（p = 0.059），FM患者的5-羟色胺水平均低于非FM患者。在FM组内，观察到5-羟色胺与压痛点计数（r = 0.563）和抑郁（r = 0.549）之间存在关联，但关联方向与先前报道和预期相反。
与非FM患者相比，FM患者的血清5-羟色胺水平显著降低，但数值范围较宽。FM患者的压痛点计数、痛觉测量、抑郁和焦虑之间存在难以解释的反向相关性。在一般人群中，5-羟色胺与任何临床变量均无相关性，且无法区分不同的疼痛组。
