MacLean C, Brahn E
Department of Medicine, UCLA School of Medicine.
J Rheumatol. 1995 Jan;22(1):177-9.
A 31-year-old woman with systemic lupus erythematosus (SLE), diabetes mellitus, and chronic renal failure developed digital ischemia, myocardial dysfunction, abnormal ECG, and elevated CPK levels. Radiographic studies revealed calcification of the peripheral vasculature although coronary angiography was unremarkable. An endomyocardial biopsy demonstrated intra and extracellular myocardial calcification without evidence of vasculitis or primary myocarditis. A diagnosis of calciphylaxis, as a result of secondary hyperparathyroidism, was made. This case demonstrates that calciphylaxis can mimic the cardiovascular manifestations of SLE. Early differentiation of these disparate diseases is important because treatment strategies employed in SLE may exacerbate calciphylaxis.
一名患有系统性红斑狼疮（SLE）、糖尿病和慢性肾衰竭的31岁女性出现了手指缺血、心肌功能障碍、心电图异常以及肌酸磷酸激酶（CPK）水平升高。影像学检查显示外周血管钙化，尽管冠状动脉造影未见明显异常。心内膜活检显示心肌细胞内和细胞外钙化，无血管炎或原发性心肌炎的证据。诊断为继发性甲状旁腺功能亢进导致的钙过敏。该病例表明，钙过敏可模仿系统性红斑狼疮的心血管表现。早期区分这些不同的疾病很重要，因为用于系统性红斑狼疮的治疗策略可能会加重钙过敏。
