Buch K, Nadgir R N, Tannenbaum A D, Ozonoff A, Fujita A, Sakai O
From the Departments of Radiology (K.B., R.N.N., A.D.T., A.F., O.S.).
AJNR Am J Neuroradiol. 2014 Mar;35(3):573-7. doi: 10.3174/ajnr.A3697. Epub 2013 Aug 14.
Trochlear calcification is frequently seen on CT scans that include the orbits, but prior studies linking this finding to diabetes mellitus were based on selected populations by using relatively thick sections. We assessed the relationship between trochlear calcification and diabetes mellitus and other chronic medical conditions in an unrestricted population by using thin-section CT.
Noncontrast head CT studies performed consecutively on 1000 patients between January and February 2011 were retrospectively reviewed for the presence of trochlear calcifications. Axial 1.25-mm-thick images acquired by 64-detector row CT were reviewed. Medical records were reviewed for chronic medical conditions, including diabetes mellitus, chronic kidney disease, alcoholism, autoimmune conditions, endocrine disorders, serum calcium and alkaline phosphatase levels, and HIV status. Motion-limited studies and patients with limited clinical data were excluded. Statistical analyses were performed by using the Fisher exact test.
Thirty-two patients were excluded from analysis. Of the remaining 968 patients, 128 had trochlear calcification (13%). No significant association was observed between diabetes mellitus and trochlear calcifications in patients of any age (P = .40). There was no significant correlation between trochlear calcifications and chronic kidney disease, alcoholism, endocrine disorders, or HIV infection. Statistically significant associations among trochlear calcification, autoimmune conditions, and elevated alkaline phosphatase levels were observed (P < .0001 and P < .0001, respectively).
On the basis of a large unrestricted population with thin-section CT imaging of the orbit, no significant association was observed between trochlear calcifications and diabetes mellitus. A statistically significant association was observed between trochlear calcification and autoimmune disease and elevated alkaline phosphatase levels.
滑车钙化在包含眼眶的CT扫描中较为常见，但先前将此发现与糖尿病相关联的研究是基于特定人群且使用相对较厚的层面。我们通过使用薄层CT评估了在无限制人群中滑车钙化与糖尿病及其他慢性疾病之间的关系。
回顾性分析2011年1月至2月间连续对1000例患者进行的非增强头部CT研究，以确定是否存在滑车钙化。对64排CT获取的1.25毫米厚的轴向图像进行了评估。查阅病历以了解慢性疾病情况，包括糖尿病、慢性肾病、酒精中毒、自身免疫性疾病、内分泌紊乱、血清钙和碱性磷酸酶水平以及HIV感染状况。排除运动受限的研究和临床数据有限的患者。采用Fisher精确检验进行统计分析。
32例患者被排除在分析之外。在其余968例患者中，128例有滑车钙化（13%）。在任何年龄的患者中，糖尿病与滑车钙化之间均未观察到显著关联（P = 0.40）。滑车钙化与慢性肾病、酒精中毒、内分泌紊乱或HIV感染之间无显著相关性。观察到滑车钙化、自身免疫性疾病和碱性磷酸酶水平升高之间存在统计学显著关联（分别为P < 0.0001和P < 0.0001）。
基于对眼眶进行薄层CT成像的大量无限制人群，未观察到滑车钙化与糖尿病之间存在显著关联。观察到滑车钙化与自身免疫性疾病以及碱性磷酸酶水平升高之间存在统计学显著关联。
