Johnson R O, Metter G, Wilson W, Hill G, Krementz E
Cancer Treat Rep. 1976 Feb;60(2):183-7.
The major toxic effects of DTIC are nausea and vomiting, leukopenia, and thrombocytopenia. It is an effective drug in the treatment of malignant melanoma with better response rates in women than in men. The addition of other drugs to DTIC therapy does not produce a higher response rate. Preliminary results indicate that as an adjuvant to standard surgical therapy DTIC does not appear beneficial to patients with a high risk for recurrence.
达卡巴嗪的主要毒性作用包括恶心、呕吐、白细胞减少和血小板减少。它是治疗恶性黑色素瘤的一种有效药物，女性的缓解率高于男性。在达卡巴嗪治疗中添加其他药物并不会产生更高的缓解率。初步结果表明，作为标准手术治疗的辅助手段，达卡巴嗪对复发风险高的患者似乎并无益处。
