Niwano Y, Ohmi T, Kanai K, Hamaguchi H, Uchida K, Yamaguchi H
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd.
Jpn J Antibiot. 1995 Jan;48(1):140-5.
In vitro antifungal activities of lanoconazole (LCZ) against 9 stock cultures and 10 clinical isolates of Candida albicans were determined using three different testing media, Sabouraud's glucose broth (SGB), Sabouraud's glucose agar (SGA) and casitone agar (CA). MIC values of LCZ against both the stock cultures and clinical isolates measured on CA distributed in a range of 0.63-5 micrograms/ml. The values were 8-64-fold lower than those obtained in SGB and on SGA. MIC ranges and the geometric mean MIC values of LCZ against stock cultures were virtually the same as those against clinical isolates, no matter which assay techniques were used. These results suggest that there is no difference in the LCZ susceptibility between stock cultures and clinical isolates of C. albicans, although anti-Candida activity of LCZ was determined to be greater on CA than that in SGB or on SGA.
使用三种不同的测试培养基，即沙保弱葡萄糖肉汤（SGB）、沙保弱葡萄糖琼脂（SGA）和酪蛋白胨琼脂（CA），测定了拉诺康唑（LCZ）对9株白色念珠菌标准菌株和10株临床分离株的体外抗真菌活性。LCZ对标准菌株和临床分离株在CA上测得的最低抑菌浓度（MIC）值范围为0.63 - 5微克/毫升。这些值比在SGB和SGA上获得的值低8 - 64倍。无论使用哪种检测技术，LCZ对标准菌株的MIC范围和几何平均MIC值与对临床分离株的几乎相同。这些结果表明，白色念珠菌标准菌株和临床分离株对LCZ的敏感性没有差异，尽管LCZ对白色念珠菌的抗真菌活性在CA上测定时比在SGB或SGA上更强。
