Mourelatos D, Mylonaki E, Papageorgiou A, Boutis L, Paradelis A, Anastasiou A, Catsoulacos P
Department of General Biology and Genetics, Medical School, Aristotle University, Thessaloniki, Greece.
Mutat Res. 1995 Mar;346(3):129-33. doi: 10.1016/0165-7992(95)90044-6.
The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chromatid exchanges (SCEs) and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumor activity of these compounds was observed.
