定量微透析法测定雄性和雌性大鼠纹状体细胞外多巴胺浓度：发情周期和性腺切除术的影响

Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy.

作者信息

Xiao L, Becker J B

机构信息

Psychology Department, University of Michigan, Ann Arbor.

出版信息

Neurosci Lett. 1994 Oct 24;180(2):155-8. doi: 10.1016/0304-3940(94)90510-x.

DOI:10.1016/0304-3940(94)90510-x

PMID:7700570

Abstract

Sex differences in basal extracellular striatal dopamine concentrations in gonadectomized male and female rats have been reported previously. In the current experiment, estrous cycle-dependent variation, sex differences and the effect of gonadectomy on extracellular striatal dopamine concentrations were determined using quantitative microdialysis. Female rats were found to have significantly higher extracellular striatal dopamine concentrations in proestrus and estrus than in diestrus or after ovariectomy. In contrast, castration of male rats had no effect on extracellular striatal dopamine concentrations. Thus, endogenous ovarian hormones, but not testicular hormones, modulate extracellular striatal dopamine concentrations in rats.

摘要

先前已有报道称，去势的雄性和雌性大鼠纹状体基底细胞外多巴胺浓度存在性别差异。在当前实验中，使用定量微透析法测定了发情周期依赖性变化、性别差异以及去势对纹状体细胞外多巴胺浓度的影响。结果发现，雌性大鼠在发情前期和发情期的纹状体细胞外多巴胺浓度显著高于动情间期或卵巢切除术后。相比之下，雄性大鼠去势对纹状体细胞外多巴胺浓度没有影响。因此，内源性卵巢激素而非睾丸激素可调节大鼠纹状体细胞外多巴胺浓度。