Guitet J, Garnier C, Ebrahimi-Gaillard A, Roger M
Laboratoire de Neurophysiologie, CNRS, URA 1869, Université de Poitiers, Faculté des Sciences, France.
Neurosci Lett. 1994 Oct 24;180(2):265-8. doi: 10.1016/0304-3940(94)90535-5.
Phaseolus vulgaris leucoagglutinin (PHA-L) was used to examine the efferent connectivity of embryonic (E16) frontal (homotopic) or occipital (heterotopic) neocortical transplants placed into--or in the vicinity of--lesion cavities made in the frontal cortex of adult recipients. Homotopic transplants projected towards the host sensorimotor cortex and, in most cases, into the lateral caudate-putamen (CPu). Heterotopic transplants projected into the anterior cingulate cortex and, in most cases, distributed terminals into the medial CPu. It is suggested that embryonic neocortical tissue placed into a damaged cortical site of an adult recipient develops a pattern of efferents corresponding to its cortical origin.
菜豆白细胞凝集素（PHA-L）被用于检测胚胎期（E16）额叶（同位）或枕叶（异位）新皮质移植到成年受体额叶皮质损伤腔或其附近后的传出连接情况。同位移植向宿主感觉运动皮质投射，并且在大多数情况下，投射到外侧尾状核-壳核（CPu）。异位移植投射到前扣带回皮质，并且在大多数情况下，将终末分布到内侧CPu。这表明植入成年受体受损皮质部位的胚胎新皮质组织会形成与其皮质起源相对应的传出模式。
