Davydov V V, Krisanova N V, Skorik G V
Patol Fiziol Eksp Ter. 1994 Oct-Dec(4):53-5.
Malonate was tested for its effects on rat hepatic metabolism of [1,4-14C]-succinic acid and [1-14C]-glycerol. The administration of malonic acid did not limit [1,4-14C]-succinate metabolism and change the rate of radioactive labelling from [1-14C]-glycerol to the total lipid fraction, as well as the fraction of phospholipids and triacylglycerides. However, there was a reduction in the use of glycerol as a precursor of higher fatty acids and cholesterol. It is suggested that the detected effect of malonate is due to its action on oxidative decarboxylation of pyruvic acid.
测试了丙二酸对大鼠肝脏中[1,4 - 14C] - 琥珀酸和[1 - 14C] - 甘油代谢的影响。丙二酸的给药并未限制[1,4 - 14C] - 琥珀酸盐的代谢，也未改变从[1 - 14C] - 甘油到总脂质部分以及磷脂和三酰甘油部分的放射性标记率。然而，甘油作为高级脂肪酸和胆固醇前体的利用有所减少。有人认为，检测到的丙二酸的作用是由于其对丙酮酸氧化脱羧的作用。
