Sillence D O
Department of Genetics, Children's Hospital, Camperdown, NSW, Australia.
Pediatr Radiol. 1994;24(6):427-30. doi: 10.1007/BF02011910.
Basilar impression (BI) assessed by either plain lateral skull radiograph or computerized tomography (CT) sagittal reconstruction of the craniocervical junction is a common finding occurring in 25% of subjects with osteogenesis imperfecta (OI). It appears to occur with highest frequency in a group of subjects with OI type IV B, i.e. patients with mild/moderate liability to fractures, normal sclerae but dentinogenesis imperfecta. Neurologic signs indicating compression of posterior fossa structures occur predominantly in subjects with BI and OI type IV. Screening is recommended for all patients with OI but particularly OI type IV B.
通过颅骨侧位平片或颅颈交界区计算机断层扫描（CT）矢状面重建评估的基底凹陷（BI）是成骨不全（OI）患者中常见的表现，在25%的OI患者中出现。它似乎在一组IV B型OI患者中出现的频率最高，即骨折风险为轻度/中度、巩膜正常但牙本质生成不全的患者。提示后颅窝结构受压的神经系统体征主要出现在患有基底凹陷和IV型OI的患者中。建议对所有OI患者进行筛查，尤其是IV B型OI患者。
