Nyquist-Battie C, Cochran P K, Sands S A, Chronwall B M
Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City 64108.
Peptides. 1994;15(8):1461-9. doi: 10.1016/0196-9781(94)90124-4.
Neuropeptide Y (NPY), immunoreactive (IR), and tyrosine hydroxylase (TH)-IR nerve fibers were scarce at birth in rat heart, but increased rapidly during the first 2 postnatal weeks, reaching approximately adult levels by the third week. The sequence of development was: interatrial septum and atrial wall, free ventricular wall starting from the epicardium, and finally the atrial appendages and interventricular septum. In ventricles and atrial appendages both fiber types developed similarly. In interatrial septum and atrial walls more NPY-IR than TH-IR fibers were evident, and NPY-IR, but not TH-IR, neurons were detected in intrinsic ganglia. Double-label immunohistochemistry provided further evidence that NPY is located in ventricular and atrial noradrenergic nerves, but is also located in nonnoradrenergic nerves in atria.
出生时，大鼠心脏中的神经肽Y（NPY）免疫反应性（IR）神经纤维和酪氨酸羟化酶（TH）-IR神经纤维稀少，但在出生后的前两周迅速增加，到第三周时达到近似成年水平。发育顺序为：房间隔和心房壁，从心外膜开始的游离心室壁，最后是心耳和室间隔。在心室和心耳中，两种纤维类型的发育情况相似。在房间隔和心房壁中，NPY-IR纤维比TH-IR纤维更明显，并且在固有神经节中检测到了NPY-IR神经元，但未检测到TH-IR神经元。双重标记免疫组织化学提供了进一步的证据，表明NPY位于心室和心房的去甲肾上腺素能神经中，但也位于心房的非去甲肾上腺素能神经中。
