Kim H S, Kang J G, Rheu H M, Cho D H, Oh K W
Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Planta Med. 1995 Feb;61(1):22-5. doi: 10.1055/s-2006-957991.
Repeated administration of methamphetamine (2 mg/kg) developed reverse tolerance to the ambulation-accelerating effect. Intraperitoneal administration of ginseng total saponin (GTS, 200 mg/kg of body weight) prior to and during chronic administration of methamphetamine inhibited the development of reverse tolerance. Dopamine receptor supersensitivity was also developed in reverse tolerant mice which had received the same methamphetamine. The development of dopamine receptor supersensitivity was evidenced by the enhanced hypothermic response to apomorphine (1 mg/kg) and the enhanced ambulatory activity of apomorphine (4 mg/kg). GTS also prevented the development of dopamine receptor supersensitivity induced by the chronic administration of methamphetamine. These results show that GTS may be useful for the prevention of and therapy for the adverse action of methamphetamine. It is concluded that the development of reverse tolerance to methamphetamine may be associated with the enhanced dopamine receptor supersensitivity since both phenomena were blocked by GTS.
反复给予甲基苯丙胺（2毫克/千克）会产生对其行走加速作用的反向耐受性。在慢性给予甲基苯丙胺之前及期间腹腔注射人参总皂苷（GTS，200毫克/千克体重）可抑制反向耐受性的产生。接受相同剂量甲基苯丙胺的反向耐受小鼠也会出现多巴胺受体超敏反应。对阿扑吗啡（1毫克/千克）的体温过低反应增强以及阿扑吗啡（4毫克/千克）的行走活动增强证明了多巴胺受体超敏反应的出现。GTS还可防止因慢性给予甲基苯丙胺而诱导的多巴胺受体超敏反应的产生。这些结果表明，GTS可能对预防和治疗甲基苯丙胺的不良反应有用。得出的结论是，对甲基苯丙胺反向耐受性的产生可能与多巴胺受体超敏反应增强有关，因为这两种现象均被GTS阻断。
