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人参总皂苷抑制甲基苯丙胺诱导的多巴胺能神经元耗竭。

Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine.

作者信息

Oh K W, Kim H S, Wagner G C

机构信息

Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea.

出版信息

Planta Med. 1997 Feb;63(1):80-1. doi: 10.1055/s-2006-957610.

DOI:10.1055/s-2006-957610
PMID:9063099
Abstract

Pretreatment with ginseng total saponin (GTS) reduced the magnitude of the methamphetamine-induced dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillinic acid (HVA) depletions. It is suggested that GTS can, in part, prevent the methamphetamine-induced striatal dopaminergic depletions.

摘要

人参总皂苷(GTS)预处理可减轻甲基苯丙胺诱导的多巴胺(DA)、3,4-二羟基苯乙酸(DOPAC)和高香草酸(HVA)耗竭的程度。提示GTS可部分预防甲基苯丙胺诱导的纹状体多巴胺能神经元耗竭。

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Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene.人参皂苷Re通过抑制蛋白激酶Cδ基因,挽救甲基苯丙胺诱导的氧化损伤、线粒体功能障碍、小胶质细胞活化和多巴胺能神经元变性。
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