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Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.

作者信息

Kulanthaivel P, Janzen W P, Ballas L M, Jiang J B, Hu C Q, Darges J W, Seldin J C, Cofield D J, Adams L M

机构信息

Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717.

出版信息

Planta Med. 1995 Feb;61(1):41-4. doi: 10.1055/s-2006-957996.

DOI:10.1055/s-2006-957996
PMID:7700990
Abstract

The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.

摘要

相似文献

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