Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.
作者信息
Kulanthaivel P, Janzen W P, Ballas L M, Jiang J B, Hu C Q, Darges J W, Seldin J C, Cofield D J, Adams L M
机构信息
Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717.
出版信息
Planta Med. 1995 Feb;61(1):41-4. doi: 10.1055/s-2006-957996.
PMID:7700990
Abstract
The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.
摘要
Zotero 插件