Coksevim B, Tayyar M
Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Tokai J Exp Clin Med. 1993 Dec;18(3-6):161-5.
Isolated rat uterus preparations were used in this study. Ritodrine hydrochloride (Rit), isoxsuprine (Isox), and spironolactone (SP) were applied on the uterus which has spontaneous activity. In similar doses they produced various inhibitory effects. Also, when oxytocin (Oxt) or acetylcholine (Ach) was conducted to the isolated preparations, contractions with high tonus and low amplitude occurred. On this model we investigated the inhibitory effect of spironolactone on the contractions. We conclude that spironolactone can be utilized on the uterus as a uterine contraction inhibitory agent in well regulated doses.
本研究使用了离体大鼠子宫标本。将盐酸利托君（Rit）、异克舒令（Isox）和螺内酯（SP）应用于具有自发活动的子宫。在相似剂量下，它们产生了不同的抑制作用。此外，当向离体标本中加入缩宫素（Oxt）或乙酰胆碱（Ach）时，会出现高张力和低振幅的收缩。在该模型上，我们研究了螺内酯对收缩的抑制作用。我们得出结论，螺内酯可以以适当调节的剂量作为子宫收缩抑制剂用于子宫。
