The effect of spironolactone of the rat uterus.

Isolated rat uterus preparations were used in this study. Ritodrine hydrochloride (Rit), isoxsuprine (Isox), and spironolactone (SP) were applied on the uterus which has spontaneous activity. In similar doses they produced various inhibitory effects. Also, when oxytocin (Oxt) or acetylcholine (Ach) was conducted to the isolated preparations, contractions with high tonus and low amplitude occurred. On this model we investigated the inhibitory effect of spironolactone on the contractions. We conclude that spironolactone can be utilized on the uterus as a uterine contraction inhibitory agent in well regulated doses.