Shutkin V A, Vagner R I, Barchuk A S
Vopr Onkol. 1994;40(1-3):25-9.
Specific features of metastatic spreading of lung cancer have been compared in 258 surgical patients from families with a history of lung cancer incidence (group I) and in 861 controls (group II). Lesions in lymph nodes at various stages were more frequent in group I, metastatic spreading incidence increasing in step with stage. In is noteworthy that more frequent lesions in mediastinal lymph nodes (stage IV) were observed in group I (54.2%), as compared with 11.8% in controls (P < 0.001). Multiple lesions of lymph nodes at all stages of metastatic spreading featured prominently in 48.5% of group I, as compared with 17.0% in group II (P < 0.001). Metastatic spreading was studied versus such characteristics of primary tumor as size, histologic pattern and pattern of tumor growth.
对258例有肺癌发病家族史的手术患者（I组）和861例对照者（II组）的肺癌转移扩散的具体特征进行了比较。I组不同阶段的淋巴结病变更为常见，转移扩散发生率随阶段增加。值得注意的是，I组纵隔淋巴结（IV期）病变更为常见（54.2%），而对照组为11.8%（P<0.001）。I组48.5%的患者在转移扩散的所有阶段均有多个淋巴结病变，显著高于II组的17.0%（P<0.001）。还对转移扩散与原发肿瘤的大小、组织学类型和肿瘤生长方式等特征进行了研究。
