Azuma E, Kojima S, Kato K, Matsuyama T, Yamada Y, Kondo N, Sawada H, Hanada M, Shibata T, Tabata N, Watanabe M, Shimono Y, Deguchi T, Umemoto M, Higashikawa M, Kawasaki H, Komada Y, Sakurai M
Department of Pediatrics and Clinical Immunology, Mie University School of Medicine, Japan.
Bone Marrow Transplant. 1997 Jun;19(11):1085-7. doi: 10.1038/sj.bmt.1700795.
Graft rejection has been a problem after bone marrow transplantation for patients with severe aplastic anemia (SAA). Ten children with SAA were conditioned for bone marrow transplantation from HLA-identical siblings, using cyclophosphamide (CY, 50 mg/kg) plus antithymocyte globulin (ATG, 15 mg/kg) for 4 successive days. Marrow was infused 36 h after the last dose of CY. Cyclosporin A and methotrexate were administered as graft-versus-host disease (GVHD) prophylaxis. All patients achieved durable engraftment at follow-up of 7-41+ months (mean, 25) without significant GVHD. Since investigators have used different sources, doses, and time schedules of ATG, we compared our results with other published reports. We conclude that CY/ATG conditioning is well tolerated and effective in children with SAA.
对于重型再生障碍性贫血（SAA）患者，骨髓移植后移植物排斥一直是个问题。10名SAA患儿接受了来自 HLA 相同同胞的骨髓移植预处理，连续4天使用环磷酰胺（CY，50mg/kg）加抗胸腺细胞球蛋白（ATG，15mg/kg）。在最后一剂CY后36小时输注骨髓。给予环孢素A和甲氨蝶呤预防移植物抗宿主病（GVHD）。所有患者在7 - 41 +个月（平均25个月）的随访中均实现了持久植入，且无明显GVHD。由于研究人员使用了不同来源、剂量和时间方案的ATG，我们将我们的结果与其他已发表的报告进行了比较。我们得出结论，CY/ATG预处理对SAA患儿耐受性良好且有效。
