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禽肉瘤病毒包膜糖蛋白的免疫原性

Immunogenicity of the envelope glycoprotein of avian sarcoma virus.

作者信息

Halpern M S, Friis R R

出版信息

Proc Natl Acad Sci U S A. 1978 Apr;75(4):1962-6. doi: 10.1073/pnas.75.4.1962.

DOI:10.1073/pnas.75.4.1962
PMID:77019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392462/
Abstract

The expression of type E-specific glycoprotein in chick-helper factor-positive [chf(+)] chickens is not restricted to a certain stage of embryogenesis but persists in postembryonic life. This finding prompted an investigation of the immunogenicity of the viral envelope glycoprotein of exogenous avian sarcoma virus in chf(+) and chf(-) chickens. Sensitization of both classes of chickens resulted in the induction of detectable antibody reactivity to determinants of the glycoprotein that were type-specific as well as group-specific. Because group-specific determinants are present on type E-specific glycoprotein, these results link immunity to exogenous viral envelope glycoprotein in chf(+) chickens with autoreactivity. A model is proposed to rationalize the induction of reactivity in this system.

摘要

E型特异性糖蛋白在鸡辅助因子阳性[chf(+)]鸡中的表达并不局限于胚胎发育的某个特定阶段，而是在胚胎后生活中持续存在。这一发现促使人们对外源禽肉瘤病毒的病毒包膜糖蛋白在chf(+)和chf(-)鸡中的免疫原性进行研究。两类鸡的致敏均导致诱导出对该糖蛋白决定簇的可检测抗体反应性，这些决定簇是型特异性的以及组特异性的。由于组特异性决定簇存在于E型特异性糖蛋白上，这些结果将chf(+)鸡对外源病毒包膜糖蛋白的免疫与自身反应性联系起来。提出了一个模型来解释该系统中反应性的诱导。

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引用本文的文献

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Host Susceptibility to endogenous viruses: defective, glycoprotein-expressing proviruses interfere with infections.宿主对内源病毒的易感性：有缺陷的、表达糖蛋白的前病毒会干扰感染。
J Virol. 1981 Dec;40(3):745-51. doi: 10.1128/JVI.40.3.745-751.1981.
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Embryonic infection with the endogenous avian leukosis virus Rous-associated virus-0 alters responses to exogenous avian leukosis virus infection.内源性禽白血病病毒劳斯相关病毒-0的胚胎感染会改变对外源性禽白血病病毒感染的反应。
J Virol. 1987 Mar;61(3):722-5. doi: 10.1128/JVI.61.3.722-725.1987.
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Antigenic determinants specific to the envelope glycoprotein of exogenous avian tumor viruses.外源性禽肿瘤病毒包膜糖蛋白的特异性抗原决定簇。
J Virol. 1979 Feb;29(2):805-7. doi: 10.1128/JVI.29.2.805-807.1979.

本文引用的文献

1
Expression of the Major Viral Glycoprotein of Avian Tumor Virus in Cells of chf(+) Chicken Embryos.禽肿瘤病毒主要病毒糖蛋白在chf(+)鸡胚细胞中的表达
J Virol. 1975 May;15(5):1131-40. doi: 10.1128/JVI.15.5.1131-1140.1975.
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An avian leukosis virus related to RSV(O): properties and evidence for helper activity.一种与劳斯肉瘤病毒（O型）相关的禽白血病病毒：特性及辅助活性证据
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Kinetic differences in unresponsiveness of thymus and bone marrow cells.胸腺和骨髓细胞无反应性的动力学差异。
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Development of chicken lymphoid system. II. Synthesis of primordial immunoglobulin M by the bursa cells of chick embryo.鸡淋巴系统的发育。II. 鸡胚法氏囊细胞合成原始免疫球蛋白M
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Virion and tumor cell antigens of C-type rna tumor viruses.C型RNA肿瘤病毒的病毒粒子和肿瘤细胞抗原
Adv Cancer Res. 1974;20:275-341. doi: 10.1016/s0065-230x(08)60112-8.
6
Isolation of the major viral glycoprotein and a putative precursor from cells transformed by avian sarcoma viruses.从禽肉瘤病毒转化的细胞中分离主要病毒糖蛋白和一种假定的前体。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2342-6. doi: 10.1073/pnas.71.6.2342.
7
Presence of antigen common to avian tumor viral envelope antigen in normal chick embryo cells.正常鸡胚细胞中存在禽肿瘤病毒包膜抗原的共同抗原。
Virology. 1973 Nov;56(1):22-32. doi: 10.1016/0042-6822(73)90284-5.
8
A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus.一种对于劳斯肉瘤病毒感染性形式的形成至关重要的细胞相关因子。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):314-21. doi: 10.1073/pnas.66.2.314.
9
Hapten-specific stimulation of secondary B cells independent of T cells.半抗原对次级B细胞的特异性刺激，不依赖于T细胞。
J Exp Med. 1973 Aug 1;138(2):473-8. doi: 10.1084/jem.138.2.473.
10
Expression of endogenous ALV antigens and susceptibility to subgroup E ALV in three strains of chickens (endogenous avian C-type virus).三种鸡（内源性禽C型病毒）中内源性禽白血病病毒（ALV）抗原的表达及对E亚群ALV的易感性
Virology. 1976 Jan;69(1):50-62. doi: 10.1016/0042-6822(76)90193-8.

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