Halpern M S, Friis R R
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1962-6. doi: 10.1073/pnas.75.4.1962.
The expression of type E-specific glycoprotein in chick-helper factor-positive [chf(+)] chickens is not restricted to a certain stage of embryogenesis but persists in postembryonic life. This finding prompted an investigation of the immunogenicity of the viral envelope glycoprotein of exogenous avian sarcoma virus in chf(+) and chf(-) chickens. Sensitization of both classes of chickens resulted in the induction of detectable antibody reactivity to determinants of the glycoprotein that were type-specific as well as group-specific. Because group-specific determinants are present on type E-specific glycoprotein, these results link immunity to exogenous viral envelope glycoprotein in chf(+) chickens with autoreactivity. A model is proposed to rationalize the induction of reactivity in this system.
E型特异性糖蛋白在鸡辅助因子阳性[chf(+)]鸡中的表达并不局限于胚胎发育的某个特定阶段,而是在胚胎后生活中持续存在。这一发现促使人们对外源禽肉瘤病毒的病毒包膜糖蛋白在chf(+)和chf(-)鸡中的免疫原性进行研究。两类鸡的致敏均导致诱导出对该糖蛋白决定簇的可检测抗体反应性,这些决定簇是型特异性的以及组特异性的。由于组特异性决定簇存在于E型特异性糖蛋白上,这些结果将chf(+)鸡对外源病毒包膜糖蛋白的免疫与自身反应性联系起来。提出了一个模型来解释该系统中反应性的诱导。