半抗原对次级B细胞的特异性刺激，不依赖于T细胞。
Hapten-specific stimulation of secondary B cells independent of T cells.
作者信息
Klinman N R, Doughty R A
出版信息
J Exp Med. 1973 Aug 1;138(2):473-8. doi: 10.1084/jem.138.2.473.
Abstract
Treatment of spleen cell suspensions from immunized mice with anti-theta serum and complement before transfer to nonimmune irradiated recipients reduced the degree of in vitro stimulation by hapten-homologous carrier complexes by 90%, but did not decrease at all the number of isolated precursor cells stimulated by hapten on heterologous carriers. Thus, secondary B cells can be stimulated by low concentrations of multiply substituted hapten-carrier complexes in the apparent complete absence of specific T cells.
摘要
在将免疫小鼠的脾细胞悬液转移至未免疫的受辐照受体之前，先用抗θ血清和补体处理，可使半抗原-同源载体复合物在体外的刺激程度降低90%，但完全不减少由半抗原在异源载体上刺激产生的分离前体细胞数量。因此，在明显完全没有特异性T细胞的情况下，低浓度的多重取代半抗原-载体复合物可刺激次级B细胞。
相似文献
1
Hapten-specific stimulation of secondary B cells independent of T cells.半抗原对次级B细胞的特异性刺激，不依赖于T细胞。
J Exp Med. 1973 Aug 1;138(2):473-8. doi: 10.1084/jem.138.2.473.
2
Cell co-operation and hapten--carrier complexes.细胞合作与半抗原-载体复合物
Immunology. 1975 Oct;29(4):675-85.
3
Hapten-specific IgE antibody responses in mice. II. Cooperative interactions between adoptively transferred T and B lymphocytes in the development of IgE response.小鼠对半抗原特异性的IgE抗体应答。II. IgE应答发育过程中过继转移的T淋巴细胞与B淋巴细胞之间的协同相互作用。
J Exp Med. 1973 Sep 1;138(3):538-56. doi: 10.1084/jem.138.3.538.
4
Immunologic reactions to haptens on autologous carriers. I. Participation of both thymus-derived and bone marrow-derived cells in the secondary in vitro response.对自身载体上半抗原的免疫反应。I. 胸腺来源细胞和骨髓来源细胞在体外二次反应中的参与情况。
J Exp Med. 1973 Feb 1;137(2):411-23. doi: 10.1084/jem.137.2.411.
5
Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.半抗原特异性二次B细胞应答的同种异体载体特异性增强。
J Exp Med. 1976 Nov 2;144(5):1254-62. doi: 10.1084/jem.144.5.1254.
6
Biological characteristics of T and B memory lymphocytes in the rat.大鼠T和B记忆淋巴细胞的生物学特性
J Exp Med. 1973 May 1;137(5):1275-92. doi: 10.1084/jem.137.5.1275.
7
The immune response against hapten-autologous protein conjugates in the mouse.小鼠对半抗原-自身蛋白偶联物的免疫反应。
J Exp Med. 1973 Apr 1;137(4):911-31. doi: 10.1084/jem.137.4.911.
8
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. I. Detection and characterization of hapten-reactive suppressor T-cell activity in mice immunized with hapten-isologous protein conjugate.半抗原反应性辅助性和抑制性T淋巴细胞的调节功能。I. 用半抗原-同源蛋白偶联物免疫的小鼠中半抗原反应性抑制性T细胞活性的检测与特性分析。
J Exp Med. 1977 Jul 1;146(1):74-90. doi: 10.1084/jem.146.1.74.
9
Tolerance induction in B lymphocytes but thymus-dependent antigens. T cells may abrogate B-cell tolerance induction by prevent an antibody response.B淋巴细胞对胸腺依赖性抗原的耐受性诱导。T细胞可能通过阻止抗体反应来消除B细胞的耐受性诱导。
J Exp Med. 1975 May 1;141(5):974-89. doi: 10.1084/jem.141.5.974.
10
The immune response against hapten-autologous protein conjugates in the mouse. II. Carrier specificity in the secondary anti-hapten response and evidence of the existence of specific helper cells.小鼠对半抗原-自身蛋白缀合物的免疫反应。II. 再次抗半抗原反应中的载体特异性及特异性辅助细胞存在的证据。
Scand J Immunol. 1973;2(2):189-97. doi: 10.1111/j.1365-3083.1973.tb02029.x.
引用本文的文献
1
Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.通过BCR内在信号放大激活IgG类别转换记忆B细胞可促进IgG抗体产生。
Nat Commun. 2015 Oct 13;6:8575. doi: 10.1038/ncomms9575.
2
Exploiting human memory B cell heterogeneity for improved vaccine efficacy.利用人类记忆 B 细胞异质性提高疫苗效力。
Front Immunol. 2011 Dec 15;2:77. doi: 10.3389/fimmu.2011.00077. eCollection 2011.
3
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells.细胞质衔接蛋白Grb2募集到表面IgG和IgE为类别转换的B细胞提供了抗原受体内在共刺激。
Nat Immunol. 2009 Sep;10(9):1018-25. doi: 10.1038/ni.1764. Epub 2009 Aug 9.
4
Antibody-specific immunoregulation and the immunodeficiency of aging.抗体特异性免疫调节与衰老免疫缺陷
J Exp Med. 1981 Aug 1;154(2):547-51. doi: 10.1084/jem.154.2.547.
5
The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses.单克隆B细胞反应中载体特异性增强的同种异体二等分。
J Exp Med. 1975 Nov 1;142(5):1165-79. doi: 10.1084/jem.142.5.1165.
6
7
Immunogenicity of the envelope glycoprotein of avian sarcoma virus.禽肉瘤病毒包膜糖蛋白的免疫原性
Proc Natl Acad Sci U S A. 1978 Apr;75(4):1962-6. doi: 10.1073/pnas.75.4.1962.
8
The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.新生BALB/c小鼠中针对2,4-二硝基苯基和2,4,6-三硝基苯基决定簇的B细胞库特征分析
J Exp Med. 1975 May 1;141(5):1133-46. doi: 10.1084/jem.141.5.1133.
本文引用的文献
1
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
2
The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis.对半抗原-蛋白质偶联物二次反应中的载体效应。I. 用转移细胞测量效应及对局部环境假说的异议
Eur J Immunol. 1971 Jan;1(1):10-7. doi: 10.1002/eji.1830010103.
3
STUDIES ON DELAYED HYPERSENSITIVITY. I. INFERENCES ON THE COMPARATIVE BINDING AFFINITIES OF ANTIBODIES MEDIATING DELAYED AND IMMEDIATE HYPERSENSITIVITY REACTIONS IN THE GUINEA PIG.迟发型超敏反应研究。I. 关于介导豚鼠迟发型和速发型超敏反应的抗体相对结合亲和力的推论
J Exp Med. 1965 Jun 1;121(6):873-88. doi: 10.1084/jem.121.6.873.
4
QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS.使用铬-51标记靶细胞对小鼠H-2抗体进行定量滴定
Transplantation. 1965 May;3:423-31. doi: 10.1097/00007890-196505000-00011.
5
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
6
IMMUNOLOGICAL SPECIFICITY OF THE SECONDARY RESPONSE WITH DINITROPHENYLATED PROTEINS.二硝基苯基化蛋白质二次反应的免疫特异性
Proc Soc Exp Biol Med. 1963 Oct;114:72-6. doi: 10.3181/00379727-114-28589.
7
8
Interaction between lymphocytes in immune responses.免疫反应中淋巴细胞之间的相互作用。
Cell Immunol. 1971 Oct;2(5):469-95. doi: 10.1016/0008-8749(71)90057-8.
9
Heterologous carriers in the anamnestic antihapten response.回忆性抗半抗原反应中的异源载体
J Exp Med. 1968 Apr 1;127(4):717-30. doi: 10.1084/jem.127.4.717.
10
Studies on immunological paralysis. VI. Thymic-independence of tolerance and immunity to type 3 pneumococcal polysaccharide.免疫麻痹研究。VI. 对3型肺炎球菌多糖的耐受性和免疫的胸腺非依赖性。
Cell Immunol. 1971 Dec;2(6):614-26. doi: 10.1016/0008-8749(71)90009-8.
Zotero 插件