Synthesis and pharmacological screening of novel 10-substituted diazepino-[2,1-f]-purines.
作者信息
Pawłowski M, Drabczyńska A, Gorczyca M, Malec D, Modzelewski J
机构信息
Department of Pharmaceutical Chemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland.
出版信息
Acta Pol Pharm. 1994;51(4-5):385-91.
PMID:7701952
Abstract
Two series of N10 substituted derivatives of 1,3-dimethyl-2,4,9-trioxo-1,3,6,7,8,10-hexahydro-1,3-diazepino+ ++-[2,1-f]- purine and 1,3-dimethyl-2,4-dioxo-1,3,6,7,8,9-hexahydro-10H-1,3-dizepino- [2,1-f]-purine were synthesized and tested for CNS activity. The most active in central nervous system tests were compounds [II] and [XIV].
摘要
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