新型四氢嘧啶并-[2,1-f]-嘌呤的化学和药理性质
Chemical and pharmacological properties of new tetrahydropyrimido-[2,1-f]-purines.
作者信息
Pawłowski M, Drabczyńska A, Gorczyca M, Malec D, Modzelewski J
机构信息
Department of Pharmaceutical Chemistry, Collegium Medicum of the Jagiellonian University, Krakow, Poland.
出版信息
Pharmazie. 1995 Jul;50(7):453-5.
PMID:7675886
Abstract
Following a research program on piperazinoalkyl-substituted tricyclic purines, a number of N-9-aryl(alkyl)-piperazinopropyl substituted tetrahydropyrimido-[2,1-f]-purines were synthesized and tested pharmacologically with respect to their influence on the central nervous system. Two of the new compounds induced hypothermia and decreased the spontaneous locomotor activity of mice.
摘要
在对哌嗪基烷基取代的三环嘌呤进行研究之后，合成了多种N-9-芳基（烷基）-哌嗪基丙基取代的四氢嘧啶并[2,1-f]嘌呤，并对其对中枢神经系统的影响进行了药理学测试。其中两种新化合物可引起体温过低并降低小鼠的自发运动活性。
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