Jung K, Scheifler A, Schulze B D, Scholz M
Department of Urology, University Hospital Charité, Humboldt University Berlin, Germany.
Am J Kidney Dis. 1995 Apr;25(4):584-8. doi: 10.1016/0272-6386(95)90127-2.
The authors studied the effect of dialysate buffer composition on the serum lipid values in male patients undergoing maintenance hemodialysis. Twenty patients on acetate and 21 patients on bicarbonate hemodialysis were investigated. The serum concentrations of high-density lipoprotein (HDL)-, HDL2- and HDL3-cholesterol were significantly lower in patients on acetate than in those on bicarbonate dialysis. The results of this study suggest possible adverse effects of acetate hemodialysis on serum HDL-cholesterol compared with bicarbonate hemodialysis. Other possibly contributory factors such as age and time on dialysis could be excluded. However, a possible role of differences in drug therapy between acetate- and bicarbonate-treated dialysis patients could not be entirely excluded.
作者研究了透析液缓冲液成分对维持性血液透析男性患者血脂值的影响。对20例接受醋酸盐透析的患者和21例接受碳酸氢盐透析的患者进行了调查。接受醋酸盐透析的患者血清高密度脂蛋白（HDL）、HDL2和HDL3胆固醇浓度显著低于接受碳酸氢盐透析的患者。该研究结果表明，与碳酸氢盐透析相比，醋酸盐血液透析可能对血清HDL胆固醇产生不良影响。其他可能的影响因素，如年龄和透析时间，可以排除。然而，醋酸盐和碳酸氢盐治疗的透析患者之间药物治疗差异的可能作用不能完全排除。
