Biedert S, Förstl H, Hewer W
Neurolog. Abteilung, Psychiatrisches Landeskrankenhaus, Wiesloch, Germany.
Angiology. 1995 Feb;46(2):129-35. doi: 10.1177/000331979504600206.
Primary degenerative dementia of the Alzheimer type (DAT) and multiinfarct dementia (MID) exhibit differences in cerebrovascular blood flow velocity profiles, which were investigated by means of transcranial Doppler sonography. The pulsatility indices, as angle-independent parameters of peripheral vascular resistance, measured in middle cerebral and basilar arteries of patients with MID, were significantly increased (P < 0.005) with respect to cases of primary DAT and to healthy age-matched controls. Approximately 75% of all MID patients exhibited small-vessel disease rather than thromboembolism from the extracranial arteries and the heart, as judged by extracranial and transcranial Doppler sonographies, computerized cerebral tomographies, EEGs, and, if necessary, 2-D echocardiographies.
采用经颅多普勒超声检查法对阿尔茨海默型原发性退行性痴呆（DAT）和多发梗死性痴呆（MID）患者脑血管血流速度分布的差异进行了研究。作为外周血管阻力的角度无关参数，在MID患者大脑中动脉和基底动脉测量的搏动指数相对于原发性DAT患者及年龄匹配的健康对照者显著升高（P < 0.005）。根据颅外和经颅多普勒超声检查、计算机断层扫描、脑电图以及必要时的二维超声心动图判断，所有MID患者中约75%表现为小血管疾病，而非颅外动脉和心脏的血栓栓塞。
