von Heijne G
Department of Biochemistry, Stockholm University, Sweden.
Bioessays. 1995 Jan;17(1):25-30. doi: 10.1002/bies.950170107.
Integral membrane proteins are found in all cellular membranes and fulfil many of the functions that are central to life. A critical step in the biosynthesis of membrane proteins is their insertion into the lipid bilayer. The mechanisms of membrane protein insertion and folding are becoming increasingly better understood, and efficient methods for the ab initio prediction of three-dimensional protein structure from the primary amino acid sequence may be within reach. Already, the basic tools needed for engineering and de novo design of integral membrane proteins seem to be at hand.
整合膜蛋白存在于所有细胞膜中，并履行许多对生命至关重要的功能。膜蛋白生物合成中的一个关键步骤是将它们插入脂质双层。膜蛋白插入和折叠的机制正越来越为人所理解，从氨基酸一级序列从头预测三维蛋白质结构的有效方法可能指日可待。目前，工程化和从头设计整合膜蛋白所需的基本工具似乎已经具备。
