Ladomery M, Sommerville J
School of Biological and Medical Sciences, University of St Andrews, Fife, Scotland.
Bioessays. 1995 Jan;17(1):9-11. doi: 10.1002/bies.950170104.
Members of the Y-box (YB) family of transcription factors are expressed in a wide range of cell types and are implicated in the regulation of a rapidly increasing number of genes. Although the biological activities of YB proteins appear to be varied, distinct patterns, relating to the timing of their expression and the identity of their target genes, are beginning to emerge. A recent report by Ito et al. focusses attention on cell proliferation and adds support to earlier suggestions that a primary function of YB proteins is to help activate growth-associated genes.
Y盒（YB）转录因子家族的成员在多种细胞类型中表达，并参与调控越来越多的基因。尽管YB蛋白的生物学活性似乎多种多样，但与其表达时间和靶基因身份相关的不同模式已开始显现。伊藤等人最近的一份报告将注意力集中在细胞增殖上，并为早期关于YB蛋白的主要功能是帮助激活生长相关基因的观点提供了支持。
