YB-1 在癌症干性、转移和耐药性中的功能的全面综述。
A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance.
机构信息
Department of Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.; MetroHealth Medical Center, Rammelkamp Center for Research, R457, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
MetroHealth Medical Center, Rammelkamp Center for Research, R457, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
出版信息
Cell Signal. 2021 Sep;85:110073. doi: 10.1016/j.cellsig.2021.110073. Epub 2021 Jul 3.
Abstract
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain protein family with multifunctional properties both in the cytoplasm and inside the nucleus. YB-1 is also involved in various cellular functions, including regulation of transcription, mRNA stability, and splicing. Recent studies have associated YB-1 with the regulation of the malignant phenotypes in several tumor types. In this review article, we provide an in-depth and expansive review of the literature pertaining to the multiple physiological functions of YB-1. We will also review the role of YB-1 in cancer development, progression, metastasis, and drug resistance in various malignancies, with more weight on literature published in the last decade. The methodology included querying databases PubMed, Embase, and Google Scholar for Y box binding protein 1, YB-1, YBX1, and Y-box-1.
摘要
Y 盒结合蛋白 1（YB-1）是高度保守的冷休克结构域蛋白家族的成员，在细胞质和细胞核内具有多种功能。YB-1 还参与各种细胞功能，包括转录调控、mRNA 稳定性和剪接。最近的研究将 YB-1 与几种肿瘤类型中恶性表型的调节联系起来。在这篇综述文章中，我们对 YB-1 的多种生理功能的文献进行了深入和广泛的回顾。我们还将回顾 YB-1 在癌症发展、进展、转移和各种恶性肿瘤中的耐药性中的作用，重点关注过去十年发表的文献。方法包括在 PubMed、Embase 和 Google Scholar 数据库中查询 Y 盒结合蛋白 1、YB-1、YBX1 和 Y-box-1。
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