Wang L C, Cohen M E, Duffner P K
Department of Neurology, State University of New York at Buffalo.
Pediatr Neurol. 1994 Nov;11(4):273-7. doi: 10.1016/0887-8994(94)90001-9.
The last major review of the etiologies of central diabetes insipidus in children was performed a quarter century ago, prior to the development of modern neuroimaging techniques. We retrospectively reviewed the records of children with central diabetes insipidus identified at Children's Hospital of Buffalo from 1979 to 1992. Of the 35 patients identified, 27 were males and 8 were females. Their ages ranged from 3 weeks to 20 years. Nineteen children had brain tumors, 7 had cerebral malformations, 3 had central nervous system infections, 1 had traumatic brain injury, and 5 were considered idiopathic. Patients with brain death were excluded from the review. Thirty-one of 35 patients developed diabetes insipidus in conjunction with other endocrinopathies. Brain tumor and its treatment account for the most common cause. Cranial magnetic resonance imaging has improved the identification of structural lesions and the understanding of the pathophysiology of central diabetes insipidus.
对儿童中枢性尿崩症病因的上一次重大综述是在四分之一个世纪前进行的，当时现代神经成像技术尚未发展。我们回顾性地查阅了1979年至1992年在布法罗儿童医院确诊的中枢性尿崩症患儿的病历。在确诊的35例患者中，27例为男性，8例为女性。他们的年龄从3周大到20岁不等。19名儿童患有脑肿瘤，7名患有脑畸形，3名患有中枢神经系统感染，1名患有创伤性脑损伤，5名被认为是特发性的。脑死亡患者被排除在本次综述之外。35例患者中有31例并发其他内分泌疾病。脑肿瘤及其治疗是最常见的病因。头颅磁共振成像改善了对结构性病变的识别以及对中枢性尿崩症病理生理学的理解。
