Karpińska G, Mazurek A P
Drug Institute, Warsaw, Poland.
Z Naturforsch C J Biosci. 1995 Jan-Feb;50(1-2):143-7. doi: 10.1515/znc-1995-1-221.
The recognition and the activation mechanism of the H3 histamine receptor was studied based on quantum-chemical calculations. A mechanistic model proposed both for recognition and activation stage clarifies different properties of histamine and alpha-methylhistamine at the H3 receptor. Interaction with a hypothetical receptor sites leads to the opening of the intramolecular hydrogen bonding in histamine, whereas the alpha-methylhistamine remains in closed conformation.
基于量子化学计算研究了H3组胺受体的识别和激活机制。针对识别和激活阶段提出的一种机制模型阐明了组胺和α-甲基组胺在H3受体上的不同特性。与假设的受体位点相互作用导致组胺分子内氢键的打开，而α-甲基组胺则保持封闭构象。
