Mazurek A P, Karpińska G
Drug Institute, Warsaw, Poland.
Z Naturforsch C J Biosci. 1994 Jul-Aug;49(7-8):471-5. doi: 10.1515/znc-1994-7-813.
The determinants for recognition at H3 histamine receptors are considered. Findings based on quantum-chemical calculations suggest that H3 histamine receptor is less hydrophilic than the H2. The form most likely to be recognized by the H3 receptor is an intramolecularly hydrogen-bonded form of alpha-methylhistamine. Receptor environment and hydration effects of active form of histamine analogs are of crucial importance.
本文探讨了H3组胺受体识别的决定因素。基于量子化学计算的结果表明，H3组胺受体的亲水性低于H2组胺受体。H3受体最可能识别的形式是α-甲基组胺的分子内氢键形式。组胺类似物活性形式的受体环境和水合作用至关重要。
